Brain Injury Knowledge Ontology (BIKO)

Welcome to the page for BIKO, a multi-species translational traumatic brain injury ontology to assist in formalizing concepts and methods used in traumatic brain injury research. BIKO creates a standardized model to describe methods and outcome measures used within preclinical and clinical TBI therapy studies to facilitate comparison across studies and models.

• The first version of BIKO focuses on modeling the major preclinical TBI models, e.g., Controlled Cortical Impact Model, Fluid Percussion Model, and Weight-Drop Model), major neurological injuries related to these models and their relationship to clinical pathophysiology. Releases are available on Github

References describing BIKO are listed below

Surles-Zeigler MC, Sincomb T, Dixon CE, Imam F, Gillespie T, Grethe JS, Ferguson AR, Martone ME. Brain Injury Knowledge Ontology (BIKO) for traumatic brain injury: Formalizing concepts and methods used in translational traumatic brain injury research bioRxiv 2023.10.29.564650; doi: https://doi.org/10.1101/2023.10.29.564650